Marieb Human Anatomy & Physiology, 12th Edition © 2025

With its big picture organization and conversational style, Marieb Human Anatomy & Physiology, published by Pearson, connects with today’s students so they gain a deep understanding of A&P for nursing, health, exercise science, and other fields.

  • Unique chapter-opening roadmaps
  • This program is accompanied by Pearson’s Mastering® platform with eText
  • Greater variety and range of self-assessment questions
  • Reworked Clinical Case Studies with NCLEX-Style questions
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Marieb Human Anatomy & Physiology Curriculum with Digital Resources

Guide students through human anatomy and physiology with a cohesive science program that teaches to their learning style.

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Big Picture Thinking



More Making Connections questions appear in every chapter challenging students to relate different concepts across body systems and chapters.

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Active Reading Guide



NEW! Active Reading Guide supports students in actively reading their A&P text. Students can download editable sheets from the Study Area in Mastering A&P. They’re also available with an Answer Key in the Instructor Resources in Mastering.

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Support Learners at Every Level


NEW! Assignable eText provides students with an all-inone learning experience: all of their assignments including reading are integrated into one place.

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Motivate and Prepare Students for Real-World Problems

Updated Career Connections videos feature real health care professionals and include assignable questions. Learners apply chapter content to examples from everyday work in healthcare.

Marieb Human Anatomy & Physiology Teaching Solutions

  • Updated Content
  • Visual Clarifications
  • Novice to Expert Support
  • Clinical Career Preparation
  • Mastering A&P Digital Toolkits
  • Instructor Resources

  • NEW! Updated Content
    We include the newest research on mRNA vaccines, the glymphatic system, localized protein synthesis in the axon of a neuron, a fourth meningeal membrane (SLYM) that divides the subarachnoid space into two compartments, revised developmental pathway of neutrophils and monocytes, new evidence for the association of specific viruses with the development of diabetes and multiple sclerosis, updated hypertension values reflecting 2021 AHA guidelines, and many more topics. Updated and new Homeostatic Imbalance and other clinical features reflect advances in our understanding and treatment of disorders: e.g., opiate addiction, Duchenne muscular dystrophy, sickle-cell anemia, amyotrophic lateralsclerosis, cystic fibrosis, and glomerulonephritis.
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  • NEW! Figure Animations
    NEW! Figure Animations are embedded in the eText and reinforce book-specific concepts in focused animations of key figures from the textbook. Each animation includes embedded “Quick Check” questions that provide the correct answer as soon as the student answers the question. Interactive activities of the animations are also assignable in Mastering.
  • Coaching Activities
    Focus Figure Coaching Activities can be assigned online through Mastering® A&P as figure walkthrough videos with assessments or multi-part coaching activities.
  • Mini Animation Coaching
    New Focus Figures can be assigned with new “mini animation” coaching activities in Mastering® A&P.
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  • Summary Tables
    13 additional Summary Tables present key information and serve as “one-stop shopping” student tools
  • Check Your Understanding Questions
    Check Your Understanding questions in each chapter now include a greater variety of and range of question types, including higher-level questions labeled Apply, Predict, What If?, Draw, and Make Connections.
  • New Visual Questions
    Dozens of new visual questions ask students to label structures or interpret visual information.
  • Draw Questions
    “Draw” Questions ask students to create visuals that reinforce concepts by drawing a structure, annotating a figure, or creating a summary table.
  • Including Illustrations
    47 Check Your Understanding questions include an illustration as part of the question and require students to practice visual literacy skills.
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  • Clinical Case Studies
    Updated Clinical Case Studies with new NCLEX-Style questions challenge students to apply knowledge to realistic clinical scenarios and appear at the end of chapters 5-29. Students can practice answering these questions on their own or in collaboration with classmates.
  • Homeostatic Imbalance Discussions
    Updated Homeostatic Imbalance discussions alert students to the consequences of body systems not functioning optimally. Relevant photos have been added to selected discussions for visual reinforcement. These sections discuss many common pathological conditions as a way of clarifying and illuminating normal body function.
  • Clinical Photos
    Relevant clinical photos have been added to selected discussions for visual reinforcement.
  • NEW! TEAS and HESI Exam Practice Questions
    NEW! TEAS and HESI exam practice questions help students prep for nursing school entrance exam with 150 TEAS and 300 HESI multiple-choice questions with wrong-answer feedback for all questions.
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  • NEW! Assignable eText
    NEW! Assignable eText provides students with an all-in one learning experience: all of their assignments including reading are integrated into one place. Instructors can choose to assign all or specific sections of a chapter as well as coaching activities, drag-and-drop assignments, dynamic study modules, and more in Mastering for autograding.
  • NEW! Assignment Manager
    NEW! Assignment Manager makes it easier and quicker to create assignments in Mastering.
  • NEW! Gap Finder: A&P Diagnostic Assessment
    NEW! Gap Finder: A&P Diagnostic Assessment contains approximately 154 questions based on 5 topics: Study Skills, Math Essentials, Chemistry Basics, Cell Biology Basics, and Biology Basics. Instructors can deselect as many questions as they want. There’s no minimum number they have to adhere to in order for the program to work.
  • NEW! Practice Anatomy Lab 4.0
    NEW! Practice Anatomy Lab 4.0 featuring fully interactive 3-D models and custom assignability in Mastering.
  • NEW! Histology Videos
    NEW! Histology Videos include 10 new videos of histology tissues that provide short, focused walk-throughs of commonly covered tissue types in A&P.
  • Interactive Physiology 2.0
    Expanded mobile-ready interactive Physiology 2.0 tutorials teach students complex physiology processes using exceptionally clear animations, interactive tutorials, games, and quizzes that can teach on the go.
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  • Instructor Resources
    This area of Mastering provides one stop shopping for PowerPoint Lecture Presentations, all figures in JPEG and PPT format, Instructor Guide, Test Bank, animations, videos, Interactive Physiology (including the worksheets), Clinical Case Studies with Teaching Strategies and case study worksheets, PAL 4.0 Resources and Test Bank, and PhysioEx Resources and Test Bank.
  • NEW! Teaching Strategies for Active Learning
    NEW! Teaching Strategies for Active Learning is an invaluable resource for instructors looking for strategies for actively engaging students in the classroom. Edited by Cathy Whiting, this manual includes over 40 hands-on activities for key topics in A&P submitted by thought leaders across the country. Each activity is tied to HAPS Learning Outcomes and includes estimated time for the activity.
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Mastering® Anatomy and Physiology from Pearson

Interactive Physiology® (IP) 2.0 and PhysioEx™ 10.0 Laboratory Simulations in Physiology are among the features that make the Pearson Mastering platform a powerful teaching and learning tool.

School Stories

In these inspirational stories, you'll learn about what schools and districts from across the country are doing to help students succeed and shape the future of education.

Get Inspired

More About Marieb Human Anatomy & Physiology

  • Table of Contents

    Unit 1. Organization of the Body

    1. The Human Body: An Orientation
    2. Chemistry Comes Alive
    3. Cells: The Living Units
    4. Tissue: The Living Fabric

    Unit 2. Covering, Support, and Movement of the Body

    1. The Integumentary System
    2. Bones and Skeletal Tissue
    3. The Skeleton
    4. Joints
    5. Muscles and Muscle Tissue
    6. The Muscular System

    Unit 3. Regulation and Integration of the Body

    1. Fundamentals of the Nervous System and Nervous Tissue
    2. The Central Nervous System
    3. The Peripheral Nervous System and Reflex Activity
    4. The Autonomic Nervous System
    5. The Special Senses
    6. The Endocrine System

    Unit 4. Maintenance of the Body

    1. Blood
    2. The Cardiovascular System: The Heart
    3. The Cardiovascular System: Blood Vessels
    4. The Lymphatic System and Lymphoid Organs and Tissues
    5. The Immune System: Innate and Adaptive Body Defenses
    6. The Respiratory System
    7. The Digestive System
    8. Nutrition, Metabolism, and Energy Balance
    9. The Urinary System
    10. Fluid, Electrolyte, and Acid-Base Balance

    Unit 5. Continuity

    1. The Reproductive System
    2. Pregnancy and Human Development
    3. Heredity
  • Elaine N. Marieb Author Bio

    Elaine N. Marieb (1936–2018) received her Ph.D. in zoology from the University of Massachusetts at Amherst. Shortly after she joined the faculty of the biology department at Holyoke Community College, Elaine famously enrolled in a nursing degree program while she was teaching anatomy and physiology to aspiring nursing students. This unique experience gave Elaine special insights into the foundational knowledge that nurses needed to master. Armed with this insight and a clear talent for teaching and writing, Elaine authored Human Anatomy & Physiology, which became an immediate hit with instructors and students. A critical part of Elaine’s legacy is The Elaine Nicpon Marieb Charitable Foundation. The foundation has helped fund numerous science and nursing programs and scholarships at the College of Nursing at the University of Massachusetts, Florida Gulf Coast University, Holyoke Community College, and Mount Holyoke College as well as sponsoring the Human Anatomy & Physiology Society (HAPS) Marieb, Hoehn, Haynes, & Abbott Award for Diversity, Equity, and Inclusion.

  • Katja Hoehn Author Bio

    Katja Hoehn is a professor emerita in the Department of Biology at Mount Royal University in Calgary, Canada. Katja’s first love is teaching. Her teaching excellence has been recognized by several awards during her 30 years at Mount Royal University. Katja received her M.D. (with Distinction) from the University of Saskatchewan, and her Ph.D. in pharmacology from Dalhousie University. She has written numerous research papers in neuroscience and pharmacology, and received a Dalhousie Medical Research Foundation Award for excellence in medical research, and a Career Achievement Award from Mount Royal University. Katja likes to spend time outdoors hiking, skiing, and competing in long-course triathlons. She also plays Irish flute down at the local pub.

  • Lawrence W. Haynes Author Bio

    Lawrence W. Haynes was awarded both his bachelor’s (in biological sciences, 1980) and Ph.D. (in physiology, 1984) degrees by the University of California, Davis. After research stints at the University of Texas Medical Branch in Galveston and the Howard Hughes Medical Institute at Johns Hopkins School of Medicine, he joined the Department of Physiology at the University of Calgary Medical School in 1989, where he enjoyed teaching medical students and graduate students. His main area of interest has always been phototransduction, and he has published a number of papers on the cGMP-gated channels of photoreceptors. He has been involved with this book (behind the scenes) for as long as his partner, Katja, and has authored or revised many Interactive Physiology modules and figure animations. Together, Larry and Katja provide financial support for students in the form of the Hoehn-Haynes scholarship that they established in 2006 for nursing students at Mount Royal University. Larry likes to ski and hike with Katja…but draws the line at triathlons.

  • Matthew A. Abbott Author Bio

    Matthew A. Abbott earned his bachelor’s degree in biology at Grinnell College and his Ph.D. in genetics at Iowa State University. In 2007, he joined the faculty at Des Moines Area Community College, where he is passionately devoted to helping students learn anatomy and physiology as they prepare for a career in nursing or other allied health fields. For many years, he has contributed to ancillary materials for this textbook as a reviewer and author. Dr. Abbott is a member of the Human Anatomy and Physiology Society (HAPS) and the Iowa Association of Community College Biology Teachers (IACCBT). In addition to his love for teaching, he enjoys biking and has participated in RAGBRAI, an annual bicycle ride across his home state of Iowa, over 25 times.

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